Reader Conributions

The Indiana University Bloomington Center for Genomics and Bioinformatics (CGB) seeks a Research Associate to serve in the genomics lab.

The goal of this book is to introduce readers to the fundamental concepts of RNA-seq experiments and guide them through the process of data analysis. This book covers experimental design, sequencing library, quality control on raw data, alignment of reads ...

The composition and density of immune cells in the tumor microenvironment (TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow cytometry, immunohistochemistry staining or single-cell sequencing are often unavailable such that we rely on computational methods to estimate ...

As part of the development of Independent Data Lab (IDL), I found myself often faced with skepticism and reluctance of bioinformatics group leaders to work together with IDL for the mere fact that it was a commercial organization and not ...

Despite being genetically diverse, bacterial pathogens can adapt to similar stressful environments in human host, but how this diversity allows them to achive this is yet not fully understood. Knowledge gained through comparative genomics...

Although messenger RNAs are key molecules for understanding life, until now, no method has existed to determine the full-length sequence of endogenous mRNAs including their poly(A) tails. Moreover, although non-A nucleotides can be incorporated in poly(A)...

BioTuring has recently launched their Big Data Portal. This enables scientists worldwide to connect to their server and analyze in real time the largest collections of single-cell datasets. With a lot of engineering effort (100X in speed improvement of gene ...

Advances in single-cell technologies have enabled the investigation of T cell phenotypes and repertoires at unprecedented resolution and scale. Bioinformatic methods for the efficient analysis of these large-scale datasets are instrumental for...

RNA-sequencing is nowadays the standard experimental approach for accurate transcriptome profiling. A key factor to help a wide range of...

A rare disease to decode the functional link between DNA methylation and maintenance of centromere integrityDNA methylation and centromere integrity are two important arms of genome maintenance, and their alterations are invariably associated with...