Databases

Fusion genes are chimeric results originated from previous separate genes with aberrant functions. The resulting protein products may lead to abnormal status of expression levels, functions and action sites, which in return may cause the abnormal proliferation of cells and ...

Accessing and exploring large-scale genomics data sets remains a significant challenge to researchers without specialist bioinformatics training. A team led by researchers at Umeå University, Sweden have developed the integrated PlantGenIE.org platform for exploration of Populus, conifer and Arabidopsis genomics data, ...

The New GeneCards® Powers LifeMap’s NGS Analysis and Interpretation Platform Enables Rapid Integration with Partners in the NGS Storage, Analysis and Interpretation Markets and Will Allow for Partnering Opportunities New User Interface, Functionality and Application Programming Interface (“API”) API Provide ...

Ongoing advances in high-throughput technologies have facilitated accurate proteomic measurements and provide a wealth of information on genomic and transcript level. In proteogenomics, this multi-omics data is combined to analyze unannotated organisms and to allow more accurate sample-specific predictions. Existing ...

Recent transcriptome annotation using deep sequencing approaches have annotated a large number of long non-coding RNAs in zebrafish, a popular model organism for human diseases. These studies characterized lncRNAs in critical developmental stages as well as adult tissues. Each of ...

Products of multiexon genes, especially in higher organisms, are a mixture of isoforms with different or even opposing functions, and therefore need to be treated separately. However, most studies and available resources such as Gene Ontology provide only gene-level function ...

Staphylococcus aureus is a commensal organism that primarily colonizes the nose of healthy individuals. S. aureus causes a spectrum of infections that range from skin and soft-tissue infections to fatal invasive diseases. S. aureus uses a large number of virulence ...

The GENCODE project has collected over 10,000 human long non-coding RNA (lncRNA) genes. However, the vast majority of them remain to be functionally characterized. Computational investigation of potential functions of human lncRNA genes is helpful to guide further experimental studies ...

Scientists from the Spanish National Cancer Research Centre’s Structural Computational Biology Group, led by Alfonso Valencia, are making the largest ever catalogue of biological chimeras available to the public domain. Specifically, the new database comprises a c ollection of more ...

Protein-protein interactions (PPIs) are key to understanding diverse cellular processes and disease mechanisms. However, current PPI databases only provide low-resolution knowledge of PPIs, in the sense that “proteins”of currently known PPIs generally refer to “genes.”It is known that alternative splicing ...