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Scientists at the Yale School of Medicine (YSM) are using single-cell RNA sequencing to learn how SARS-CoV-2 interacts with a host cell. The two senior...

Despite longstanding appreciation of gene expression heterogeneity in isogenic bacterial populations, affordable and scalable technologies for studying single bacterial cells have been limited. Although single-cell RNA sequencing (scRNA-seq) has...

Alcohol-related liver disease (ALD) is a deadly condition affecting more than 150 million people worldwide with no treatment available besides transplant.But now, a team led by researchers from Massachusetts General Hospital has uncovered...

  The new coronavirus (SARS-CoV-2) outbreak from December 2019 in Wuhan, Hubei, China, has been declared a global public health emergency. Angiotensin I converting enzyme 2 (ACE2), is the host receptor by SARS-CoV-2 to infect human cells. Although ACE2 is ...

Severe fetal growth restriction is a rare yet one of the riskiest obstetric complications, requiring clinicians make decisions based on ultrasound...

Many severe symptoms in Parkinson’s disease are caused by the degeneration of the brain’s dopamine neurons. Transplantation of stem cell-derived dopamine neurons to patients with Parkinson’s disease is a therapeutic approach that is getting close to...

Mendelian disorders with cutaneous manifestations comprise a genotypically heterogeneous group of over 1,000 diseases, and in most of them mutant genes have been identified. Mutation detection...

Here, we answer some FAQs about RNA-seq and RNA sequencing libraries. What is RNA sequencing? RNA sequencing (RNA-seq) is a tool used to study the transcriptome – the total RNA molecules present in one or a collection of cells, including protein coding RNAs ...

Identifying different types of cells within a tissue or an organ can be very challenging and time-consuming. Methods to identify cell types from single-cell RNA sequencing data have been...

Ribosome profiling (Ribo-seq) is a powerful technology for globally monitoring RNA translation; ranging from codon occupancy profiling, identification of actively translated open reading frames (ORFs), to the quantification of translational efficiency under...