Single-cell RNA-Seq Gaining Steam

[Webinar] Spectrum of Single Cell Sequencing: From Single-cell RNA-seq to Spatial Transcriptomics (10/27/2020) - In contrast to whole tissue RNA sequencing, single-cell sequencing has been a promising tool in the research for medical and clinical treatments by analyzing individual cell at its microenvironments and making discoveries of unknown cell types, particularly in rare diseases. Obtaining quantitative information on gene expression changes within cells can be laborious and challenging. Spatial ...
rna-seq RNA timestamps identify the age of single molecules in RNA sequencing (10/21/2020) - Current approaches to single-cell RNA sequencing (RNA-seq) provide only limited information about the dynamics of gene expression. Researchers from MIT and the Broad Institute of Harvard and MIT present RNA timestamps, a method for inferring the age...
rna-seq scRCAT-seq reveals subtype-specific isoforms differing in transcript demarcation (10/14/2020) - The differences in transcription start sites (TSS) and transcription end sites (TES) among gene isoforms can affect the stability, localization, and translation...
Featured RNA-Seq Job – Scientist – Single-Cell Bioinformatics (10/6/2020) - This position will collaborate with an enthusiastic and dynamic team of computational and experimental scientists to build a quantitative census of cell types in mouse brain, and understand the...
Dolomite Bio releases new application on plant protoplast RNA sequencing of leaves (10/5/2020) - Dolomite Bio, a leading provider of high throughput single cell technology, launches a new application note demonstrating single cell RNA Sequencing of plant leaf protoplasts on the Nadia Innovate The Nadia Instrument exhibits unprecedented sample type and size compatibility, allowing it to provide high-throughput single cell microfluidic solutions for plant research. With the unrivalled versatility ...
rna-seq Single-cell RNA sequencing reveals details about individual cells in pancreatic tumors (10/2/2020) - TGen and HonorHealth investigators suggest this granular analysis could lead to better treatments for pancreatic cancer patients Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and...
rna-seq RainDrop – Rapid activation matrix computation for droplet-based single-cell RNA-seq reads (7/30/2020) - Obtaining data from single-cell transcriptomic sequencing allows for the investigation of cell-specific gene expression patterns, which could not be addressed a few years ago. With the advancement of droplet-based protocols the number of studied...
rna-seq Ultra-high throughput single-cell analysis of proteins and RNAs by split-pool synthesis (6/15/2020) - Single-cell omics provide insight into cellular heterogeneity and function. Recent technological advances have accelerated single-cell analyses, but workflows remain expensive and complex. Researchers at Roche Sequencing Solutions present a method enabling simultaneous, ultra-high throughput single-cell barcoding of millions of cells for targeted analysis of proteins and RNAs. Quantum barcoding (QBC) avoids isolation of single cells ...
How to Analyze Single Cell RNA-Seq Data: Point, Click, Done (6/11/2020) - How to Analyze Single Cell RNA-Seq Data: Point, Click, Done June 24, 2020 11:00 a.m. EDT ************** *REGISTER* ************** Single cell mRNA sequencing allows for the identification of different cell subtypes in a progenitor population. During pancreatic development, Neurog3 positive cells are destined to become endocrine cells generating alpha cells, beta cells, and delta cells. ...
Single-cell profiling of total RNA using Smart-seq-total (6/5/2020) - The ability to interrogate total RNA content of single cells would enable better mapping of the transcriptional logic behind emerging cell types and states. However, current RNA-seq methods are...

A slew of recent high profile papers and upcoming conferences highlight the growing interest in single-cell transcriptomics.