Next-generation sequencing (NGS) technology has become a powerful tool for dissecting the molecular and pathological signatures of a variety of human...
Read More »scREAD – A single-cell RNA-Seq database for Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the brain and the most common form of dementia among the elderly. The single-cell RNA-sequencing (scRNA-Seq) and...
Read More »SILVER-SEQ enables discovery of new exRNA biomarker in blood for Alzheimer’s disease
Researchers at the University of California San Diego discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker...
Read More »Microglial Transcriptome Hints at Shortcomings of AD Model
With the realization that microglia play a key role in neurodegenerative conditions, scientists have profiled their transcription patterns to see how they change during disease. A study published...
Read More »Researchers detect new mechanism in Alzheimer’s disease from RNA-Seq data
Rate of RNA decay could be a key to breakdown in communication between neurons McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer’s disease. Their study, published in Nature ...
Read More »RNA-Seq implicates cellular reprograming in model of Alzheimer’s disease
Neuroscientists identify genetic changes in microglia in a mouse model of neurodegeneration and Alzheimer’s disease. Microglia, immune cells that act as the central nervous system’s damage sensors, have recently been implicated in Alzheimer’s disease. The cells, a type of macrophage ...
Read More »omiRas – A MicroRNA-Seq Data Analysis Pipeline
To identify circulating miRNA biomarkers for AD, researchers from Meiji Pharmaceutical University, Japan reanalyzed a publicly available small RNA-Seq dataset, composed of blood samples derived from 48 AD patients and 22 normal control (NC) subjects, by a simple web-based miRNA ...
Read More »Transcriptomics identifies genes and signaling pathways that may regulate neurodegeneration
Society for Experimental Biology and Medicine Massive elimination of neurons is a critical aspect of normal nervous system development but also represents a defining feature of neurodegenerative pathologies, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. ...
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