Tag Archives: alzheimer’s disease

Next-generation sequencing (NGS) technology has become a powerful tool for dissecting the molecular and pathological signatures of a variety of human...

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the brain and the most common form of dementia among the elderly. The single-cell RNA-sequencing (scRNA-Seq) and...

Researchers at the University of California San Diego discovered that high blood levels of RNA produced by the PHGDH gene could serve as a biomarker...

With the realization that microglia play a key role in neurodegenerative conditions, scientists have profiled their transcription patterns to see how they change during disease. A study published...

Rate of RNA decay could be a key to breakdown in communication between neurons McGill University researchers have discovered a cellular mechanism that may contribute to the breakdown of communication between neurons in Alzheimer’s disease. Their study, published in Nature ...

Neuroscientists identify genetic changes in microglia in a mouse model of neurodegeneration and Alzheimer’s disease. Microglia, immune cells that act as the central nervous system’s damage sensors, have recently been implicated in Alzheimer’s disease. The cells, a type of macrophage ...

To identify circulating miRNA biomarkers for AD, researchers from Meiji Pharmaceutical University, Japan reanalyzed a publicly available small RNA-Seq dataset, composed of blood samples derived from 48 AD patients and 22 normal control (NC) subjects, by a simple web-based miRNA ...

Society for Experimental Biology and Medicine Massive elimination of neurons is a critical aspect of normal nervous system development but also represents a defining feature of neurodegenerative pathologies, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis. ...