RNA-Seq Blog Transcriptome Research & Industry News
Methods to differentiate human pluripotent stem cells into kidney organoids were first introduced about 5 years ago, and since that time, the field...
Read More »Impact of single cell RNA sequencing on kidney organoids research
SCODE – An efficient regulatory network inference algorithm from single-cell RNA-Seq during differentiation
The analysis of RNA-Seq data from individual differentiating cells enables us to reconstruct the differentiation process and the degree of differentiation (in pseudo-time) of each cell. Such analyses can reveal detailed expression dynamics and functional relationships for differentiation. To further ...
Read More »CellTree – an R/bioconductor package to infer the hierarchical structure of cell populations from single-cell RNA-seq data
Single-cell RNA sequencing is fast becoming one the standard method for gene expression measurement, providing unique insights into cellular processes. A number of methods, based on general dimensionality reduction techniques, have been suggested to help infer and visualise the underlying ...
Read More »Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells
The transcriptional programs that govern hematopoiesis have been investigated primarily by population-level analysis of hematopoietic stem and progenitor cells, which cannot reveal the continuous nature of the differentiation process. Here researchers from the Sanger Institute-EBI applied single-cell RNA-sequencing to a ...
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