For model species, the 3′ RNA-seq method might more accurately detect differential expression

December 5, 2016 Leave a comment 6,365 Views

One limitation of the widely used RNA-seq method is that long transcripts are represented by more reads than shorter transcripts, resulting in a biased estimation of expression levels. The 3′ RNA-seq method, which yields only one sequence per transcript, bypasses ...

Published reference genomes should be re-annotated before use as references for RNA-Seq experiments

May 27, 2016 Leave a comment 6,823 Views

RNA-seq based on short reads generated by next generation sequencing technologies has become the main approach to study differential gene expression. Until now, the main applications of this technique have been to study the variation of gene expression in a ...

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For model species, the 3′ RNA-seq method might more accurately detect differential expression

Published reference genomes should be re-annotated before use as references for RNA-Seq experiments

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