Mouse model helped team find MAARS lncRNA, which may contribute to atherosclerotic plaque buildup Atherosclerosis is marked by the buildup of inflammatory cells which narrow arteries to the...
Read More »NetMiner – an ensemble pipeline for building genome-wide and high-quality gene co-expression network using massive-scale RNA-seq samples
Accurately reconstructing gene co-expression network is of great importance for uncovering the genetic architecture underlying complex and various phenotypes. The recent availability of high-throughput RNA-seq sequencing has made genome-wide...
Read More »A RNA-Sequencing approach for the identification of novel long non-coding RNA biomarkers in colorectal cancer
Long non-coding RNAs (lncRNAs) have been implicated in human pathology, however, their role in colorectal carcinogenesis have not been fully elucidated. In the current study, researchers from Baylor...
Read More »UClncR – Ultrafast and comprehensive long non-coding RNA detection from RNA-seq
Long non-coding RNA (lncRNA) is a large class of gene transcripts with regulatory functions discovered in recent years. Many more are expected to be...
Read More »Computational prediction of lncRNA-mRNA interactions by integrating tissue specificity in the human transcriptome
Long noncoding RNAs (lncRNAs) play a key role in normal tissue differentiation and cancer development through their tissue-specific expression in the human transcriptome. Recent investigations of macromolecular interactions have shown that tissue-specific lncRNAs form base-pairing interactions with various mRNAs associated ...
Read More »Evolinc – quickly identify sequence conserved lincRNAs for functional analysis
Long intergenic non-coding RNAs (lincRNAs) are an abundant and functionally diverse class of eukaryotic transcripts. Reported lincRNA repertoires in mammals vary, but are commonly in the thousands to tens of thousands of transcripts, covering ~90% of the genome. In addition ...
Read More »A Method for Surveying the Long-RNA Landscape of Exosomes
The emergence of next-generation sequencing platforms has enabled the discovery and interrogation of RNA from tissues, biofluids, and extracellular vesicles at remarkable levels. Recently, interest has grown in sequencing RNA found in extracellular vesicles called exosomes, because of their role ...
Read More »Identification of novel long non-coding RNAs using RNA-Seq
Functional characterization of long non-coding RNAs (lncRNAs) and their pathological relevance is still a challenging task. Abnormal expression of a few long non-coding RNAs have been found associated with hepatocellular carcinoma, with potential implications to both improve our understanding of ...
Read More »RNA-Seq identifies BRCAT431 as the top lncRNA upregulated in ER-positive breast cancers
from OncologyNurseAdvisor by Joyce Pagan SAN ANTONIO, TX—In the largest reported compendia of breast cancer long noncoding RNAs (lncRNAs), BRCAT431 was identified as the top lncRNA upregulated in ER-positive breast cancers, and a novel mechanism by which this lncRNA functions ...
Read More »Probing RNA Structure in Cells Using Targeted Structure-Seq
Models for how lncRNAs function depend on thermodynamically stable secondary and higher-order structures that RNAs can form in the context of a cell. Probing accessible RNA bases can provide data to build models of RNA conformation that provide insight into ...
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