Bronchoscopy for suspected lung cancer has low diagnostic sensitivity, rendering many inconclusive results. The Bronchial Genomic Classifier (BGC) was developed to help with patient management by...
Read More »Researchers use RNA sequencing as alternative to immunohistochemistry in cancer diagnostics
The conventionally used method for cancer diagnostics relies on immunohistochemical dyeing of tumor tissue sections. It allows to detect the presence and measure the concentration of marker proteins...
Read More »Study shows single-cell RNA sequencing can be used on solid tumor liquid biopsy
Small cell lung cancer (SCLC) accounts for 14% of all lung cancers and is often rapidly resistant to chemotherapy, resulting in poor clinical outcomes...
Read More »Targeted RNA-Seq assays should be used in all cases that appear driver negative by DNA-Seq assays
Targeted next-generation sequencing of DNA has become more widely used in the management of patients with lung adenocarcinoma; however, no clear mitogenic driver alteration is found in some cases. Researchers at Memorial Sloan Kettering Cancer...
Read More »RNA-Seq reveals the extent of small RNAs representation in the human genome
While the amount of small non-coding RNA sequencing data is continuously increasing, it is still unclear to which extent small RNAs are...
Read More »Development of a RNA-Seq Based Prognostic Signature for Lung Cancer
Precision therapy for lung cancer will require comprehensive genomic testing to identify actionable targets as well as ascertain disease prognosis. RNA-seq is a robust platform that meets these requirements, but microarray-derived prognostic signatures are not optimal for RNA-seq data. Thus, ...
Read More »Biogazelle and Isis evaluate long non-coding RNAs to identify and validate novel targets for anti-cancer drugs
GHENT, Belgium, October 15, 2015 – Biogazelle NV today announced a research-stage collaboration with Isis Pharmaceuticals in which they will identify and validate novel targets to treat colon, liver and lung cancer, diseases with clear unmet clinical needs. As part ...
Read More »RNA-Seq no longer required – a new machine learning-based model predicts gene expression as a consequence of epigenetic modification
from Lung Cancer News Today by Patricia Silva Researchers at Johns Hopkins University and the University of Hawaii created a model based on epigenomics data capable of predicting differential gene expression in lung cancer. The study was recently published in ...
Read More »TRUP- Identification of novel fusion genes using breakpoint assembly of RNA-Seq data
Genomic translocation events frequently underlie cancer development through generation of gene fusions with oncogenic properties. Identification of such fusion transcripts by transcriptome sequencing might help to discover new potential therapeutic targets. A team led by researchers at the University of ...
Read More »Thermo Fisher Scientific Launches Ion Torrent AmpliSeq RNA Fusion Lung Cancer Research Panel
CARLSBAD, Calif.–(BUSINESS WIRE)–Today Thermo Fisher Scientific announced that it has released a next-generation sequencing (NGS) RNA panel and workflow that enables targeted sequencing of fusion transcripts for clinical research. The new Ion Torrent AmpliSeq RNA Fusion Lung Cancer Research Panel ...
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