Proteogenomics, i.e. comprehensive integration of genomics and proteomics data, is a powerful approach identifying novel protein biomarkers. This is especially the case for proteins that differ structurally between disease and control conditions. As tumor development is associated with aberrant splicing, ...
Read More »TranscriptCoder – Proteomic validation of transcript isoforms, including those assembled from RNA-Seq data
Human proteome analysis now requires an understanding of protein isoforms. Researchers from the University of New South Wales explore how RNA-seq transcriptomics data, and proteomic analysis of the same sample, can identify protein isoforms. RNA-seq data from human mesenchymal (hMSC) ...
Read More »SplicePie – a novel analytical approach for the detection of alternative, non-sequential and recursive splicing
Alternative splicing is a powerful mechanism present in eukaryotic cells to obtain a wide range of transcripts and protein isoforms from a relatively small number of genes. The mechanisms regulating (alternative) splicing and the paradigm of consecutive splicing have recently ...
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