Tag Archives: Single-cell RNA sequencing

Current approaches to single-cell RNA sequencing (RNA-seq) provide only limited information about the dynamics of gene expression. Researchers from MIT and the Broad Institute of Harvard and MIT present RNA timestamps, a method for inferring the age...

A large number of genes has been implicated in neurodevelopmental disorders (NDDs) such as autism, developmental delays, intellectual disabilities and epilepsy, but it is difficult to determine how these genes, individually and as a group, contribute to...

Introduction A full-time position is available within the laboratory for Molecular Neurogenetics (www.molecular-neurogenetics.lu.se) led by Johan Jakobsson. The Jakobsson lab is interested in how gene expression is regulated in the brain and how this process influence neurodegenerative diseases, psychiatric disorders and brain ...

Single-cell RNA sequencing offers snapshots of whole transcriptomes but obscures the temporal RNA dynamics. Researchers from the University of Pennsylvania have developed single-cell metabolically labeled new RNA tagging sequencing (scNT-seq), a method for massively parallel analysis of newly transcribed and ...

Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell...

Researchers at the German Center for Neurodegenerative Diseases have developed Scaden, a deep neural network for cell deconvolution that uses gene expression information to infer the cellular composition of tissues. Scaden is trained on single-cell RNA sequencing (RNA-seq) data to ...

Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor prognosis. To comprehensively characterize the HGSOC ascites ecosystem, a team...

Data offers valuable resource for developing stem cell-based therapies for hearing loss A team of researchers has generated a developmental map...

Scientists at the Yale School of Medicine (YSM) are using single-cell RNA sequencing to learn how SARS-CoV-2 interacts with a host cell. The two senior...

Many severe symptoms in Parkinson’s disease are caused by the degeneration of the brain’s dopamine neurons. Transplantation of stem cell-derived dopamine neurons to patients with Parkinson’s disease is a therapeutic approach that is getting close to...